Determination of Cardiac Reserve in Heart Failure using Pulse Wave Velocity Analysis
Heartfailure is associated with diminished cardiac output, the amplitude of thearterial pulse wave velocity (PWV), and the magnitude of the reflected wave atbaseline. With exercise, there is augmentation of contractility and systolicoutput that changes the characteristic wave form of the arterial pulse. Themain objective of this project is to develop a quantitative analysis method tocharacterize the dynamic configurations of the arterial wave forms at baselineand with cardiovascular stress. We are developing algorithms and scoring systemthat detects changes in arterial PWV between baseline/rest and peakcardiovascular stress in order to determine cardiac reserve using noninvasiveultrasound.
The desired outcome of this project is to develop a non invasive method of measuring cardiac reserve in heart failure patients.
Approximately 50% of the budget for this project will be used to support graduate students in biomedical engineering/physicals to develop computational pulse wave modeling.