Funded Research

Funded // 2021-2022 Funding Round

Animating Alzheimer's Disease

A project to develop, design, and create an original movie, animating the underlying neurobiological origins of Alzheimer's Disease, illustrating the effects of this devastating syndrome on the brain.
Molecular and Cellular Neuroscience; Arts and Humanities; Education; data science
Trio Funded
Funded // 2021-2022 Funding Round

Training the Next Generation of Scientists: Developing a Model of K-6 Science Teacher Preparation in a COVID-19 Era

COVID-19 has disrupted science instruction in schools. We propose to design, implement, and study virtual K-6 science instruction model to improve teacher training, instruction, and student learning.
Trio Funded
Funded // 2021-2022 Funding Round

Untangling the Pathophysiology of Cerebral Cavernous Malformations

We will study calcium signaling in endothelial cells derived from cerebral cavernous malformations under various shear stress conditions to instigate the development of new therapeutic strategies.
Neuroscience and Neurobiology; Pathology; Molecular and Cellular Neuroscience; Cellular and Molecular Physiology; Bioimaging and Biomedical Optics
Trio Funded
Funded // 2021-2022 Funding Round

Small molecule inhibitors of the KIX domain of EP300 - a targeted approach to small cell lung cancer

We propose to develop small molecules inhibitors of the pro-tumorigenic actions of EP300 KIX domain and assess them for potential targeted therapeutics for lung cancer.
Cancer Biology; Biochemistry, Biophysics, and Structural Biology; Medicinal-Pharmaceutical Chemistry
Trio Funded
Funded // 2021-2022 Funding Round

Phase field modeling of metal-insulator transition dynamics in correlated electron materials

We aim at developing phase field models for metal-insulator transitions in several canonical Mott insulators, and implementing state-of-the-art methods to solve the coupled dynamical equations.
Materials Science and Engineering; Condensed Matter Physics; Electrical and Electronics
Trio Funded
Funded // 2021-2022 Funding Round

Development of an Automated System to Facilitate Coding Skills through Art and Music

This initiative will employ machine learning to create an automated feedback system that facilitates development of programming skills through art and music.
Computer Sciences; Music; Education
Trio Funded
Funded // 2021-2022 Funding Round

Dissecting the origins of heterogeneous cancer cellular interactions and responses to therapeutic perturbation

We propose to integrate multiplexed single-cell measurements with novel computational methods to identify the dynamics of heterogeneous subpopulations and predict their phenotypic response to drugs.
Cancer Biology; Computational Biology; Systems Biology; Data Science
Trio Funded
Funded // 2021-2022 Funding Round

Neuro-Genetic Dynamical Systems for Viral Infection (COVID-19) Modeling and Analysis

This project entails application of hybrid intelligent system, combining techniques from artificial intelligence and mathematical modeling to study the spread patterns and dynamics of COVID-19 virus.
Trio Funded
Funded // 2021-2022 Funding Round

Personalizing breast cancer treatment using predictors from imaging and molecular data

We seek to develop novel predictors of breast cancer outcomes using new imaging technology and molecular data
Trio Funded
Funded // 2018–2019 Funding Round

Defining and Promoting Effective School Leadership for Early Childhood Education

School leadership is central to school quality and student learning, but there is limited information in early childhood education (ECE). We will examine leadership qualities of ECE principals.
Public Policy; Early Childhood Education; Education Policy
Trio Funded
Funded // 2018–2019 Funding Round

Genetically-Encoded Norepinephrine Sensors

Norepinephrine (NE) ubiquitously mediates cell-to-cell communication, yet NE transmission remains poorly understood. We aim to develop NE sensors to transform NE biological and translational research.
Biomedical Engineering and Bioengineering; Neuroscience and Neurobiology; Molecular Genetics
Trio Funded
Funded // 2018–2019 Funding Round

The Impact of Weather and Climate on Hospital and Emergency Department Admissions in Virginia

In this project, we will examine the influence of long-term, seasonal, and daily weather and climate changes on hospital and emergency department admissions in Virginia health care facilities.
Systems Engineering; Environmental Health; Environmental Sciences
Trio Funded